Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation

Factor Xa (FXa) plays a significant role in the blood coagulation cascade and it has become a promising target for anticoagulation drugs. Three oral direct FXa inhibitors have been approved by the FDA for treating thrombotic diseases. By structure-activity relationship (SAR) analysis upon these FXa...

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Bibliographic Details
Published in:Molecules
Main Authors: Wang, Wenzhi, Yuan, Jing, Fu, Xiaoli, Meng, Fancui, Zhang, Shijun, Xu, Weiren, Xu, Yongnan, Huang, Changjiang
Format: Artigo
Language:Inglês
Published: MDPI 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274369/
https://ncbi.nlm.nih.gov/pubmed/27089317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21040491
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