Fragment-Based Lead Generation of 5-Phenyl-1H-pyrazole-3-carboxamide Derivatives as Leads for Potent Factor Xia Inhibitors

FXIa is suggested as a major target for anticoagulant drug discovery because of reduced risk of bleeding. In this paper, we defined 5-phenyl-1H-pyrazole-3-carboxylic acid derivatives as privileged fragments for FXIa inhibitors’ lead discovery. After replacing the (E)-3-(5-chloro-2-(1H-tetrazol-1-yl)...

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Vydáno v:Molecules
Hlavní autoři: Wei, Qunchao, Zheng, Zhichao, Zhang, Shijun, Zheng, Xuemin, Meng, Fancui, Yuan, Jing, Xu, Yongnan, Huang, Changjiang
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222544/
https://ncbi.nlm.nih.gov/pubmed/30103465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23082002
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