Synthesis and Evaluation of (99m)Tc-Labeled Dimeric Folic Acid for FR-Targeting

The folate receptor (FR) is overexpressed in a wide variety of human tumors. In our study, the multimeric concept was used to synthesize a dimeric folate derivative via a click reaction. The novel folate derivative (HYNIC-D(1)-FA(2)) was radiolabeled with (99m)Tc using tricine and trisodium tripheny...

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Publicado no:Molecules
Main Authors: Guo, Zhide, Gao, Mengna, Song, Manli, Shi, Changrong, Zhang, Pu, Xu, Duo, You, Linyi, Zhuang, Rongqiang, Su, Xinhui, Liu, Ting, Du, Jin, Zhang, Xianzhong
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274367/
https://ncbi.nlm.nih.gov/pubmed/27338334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21060817
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