Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects

The cantharidinimide derivatives, 5a–h, including sulfanilamides containing pyrimidyl, pyrazinyl, hydrogen, thiazolyl, and oxazolyl groups were synthesized. Modification of cantharidinimide by means of the reaction of activated aziridine ring opening led to the discovery of a novel class of antitumo...

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Udgivet i:Molecules
Main Authors: Chiang, Ling-Ling, Tseng, Ing-Jy, Lin, Pen-Yuan, Sheu, Shiow-Yunn, Lin, Ching-Tung, Hsieh, Yun-Han, Lin, Yi-Jing, Chen, Hsiao-Ling, Lin, Mei-Hsiang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273973/
https://ncbi.nlm.nih.gov/pubmed/26784163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21010100
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