Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects

The cantharidinimide derivatives, 5a–h, including sulfanilamides containing pyrimidyl, pyrazinyl, hydrogen, thiazolyl, and oxazolyl groups were synthesized. Modification of cantharidinimide by means of the reaction of activated aziridine ring opening led to the discovery of a novel class of antitumo...

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Vydáno v:Molecules
Hlavní autoři: Chiang, Ling-Ling, Tseng, Ing-Jy, Lin, Pen-Yuan, Sheu, Shiow-Yunn, Lin, Ching-Tung, Hsieh, Yun-Han, Lin, Yi-Jing, Chen, Hsiao-Ling, Lin, Mei-Hsiang
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273973/
https://ncbi.nlm.nih.gov/pubmed/26784163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21010100
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