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The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2), a major player in both the “Warburg effect” and canc...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Lis, Paweł, Dyląg, Mariusz, Niedźwiecka, Katarzyna, Ko, Young H., Pedersen, Peter L., Goffeau, Andre, Ułaszewski, Stanisław
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273842/
https://ncbi.nlm.nih.gov/pubmed/27983708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21121730
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