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Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety

We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H-imidazole to enantiomerically pure N-tert-butanesulfin...

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Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Spitz, Cédric, Mathias, Fanny, Giuglio-Tonolo, Alain Gamal, Terme, Thierry, Vanelle, Patrice
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273685/
https://ncbi.nlm.nih.gov/pubmed/27827934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21111472
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