Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates with higher therapeutic efficacy than single-targeting drugs. By following the mu...

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Udgivet i:Molecules
Main Authors: Pisani, Leonardo, Farina, Roberta, Soto-Otero, Ramon, Denora, Nunzio, Mangiatordi, Giuseppe Felice, Nicolotti, Orazio, Mendez-Alvarez, Estefania, Altomare, Cosimo Damiano, Catto, Marco, Carotti, Angelo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273473/
https://ncbi.nlm.nih.gov/pubmed/26999091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21030362
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