Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

12-Aza-epothilones (azathilones) incorporating quinoline side chains and bearing different N12-substituents have been synthesized via highly efficient RCM-based macrocyclizations. Quinoline-based azathilones with the side chain N-atom in the meta-position to the C15 atom in the macrocycle are highly...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Molecules
Hlavní autoři: Jantsch, Andrea, Nieto, Lidia, Gertsch, Jürg, Rodríguez-Salarichs, Javier, Matesanz, Ruth, Jiménez-Barbero, Jesús, Díaz, J. Fernando, Canales, Ángeles, Altmann, Karl-Heinz
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273374/
https://ncbi.nlm.nih.gov/pubmed/27527129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21081010
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky