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Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units

The understanding of the mechanisms behind nucleotide recognition by Argonaute 2, core protein of the RNA-induced silencing complex, is a key aspect in the optimization of small interfering RNAs (siRNAs) activity. To date, great efforts have been focused on the modification of certain regions of siR...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Alagia, Adele, Terrazas, Montserrat, Eritja, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272285/
https://ncbi.nlm.nih.gov/pubmed/25919280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20057602
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