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Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium stores. Starting with 2′-deoxy-2′-fluoroarabin...

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Dades bibliogràfiques
Publicat a:Molecules
Autors principals: Wang, Shengjun, Zhu, Wenjie, Wang, Xuan, Li, Jianguo, Zhang, Kehui, Zhang, Liangren, Zhao, Yong-Juan, Lee, Hon Cheung, Zhang, Lihe
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271716/
https://ncbi.nlm.nih.gov/pubmed/25268725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191015754
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