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Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase
Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium stores. Starting with 2′-deoxy-2′-fluoroarabin...
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| Veröffentlicht in: | Molecules |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6271716/ https://ncbi.nlm.nih.gov/pubmed/25268725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191015754 |
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