Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal

The extracellular domain of human CD38 is a multifunctional enzyme involved in the metabolism of two Ca(2+) messengers, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). When NAD is used as a substrate, CD38 predominantly hydrolyzes it to ADP-ribose with a trace mo...

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Bibliographic Details
Main Authors: Zhang, HongMin, Graeff, Richard, Chen, Zhe, Zhang, LiangRen, Zhang, LiHe, Lee, HonCheung, Hao, Quan
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019291/
https://ncbi.nlm.nih.gov/pubmed/21134381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.11.044
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