PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase

The helicase portion of the hepatitis C virus nonstructural protein 3 (NS3) is considered one of the most validated targets for developing direct acting antiviral agents. We isolated polybrominated diphenyl ether (PBDE) 1 from a marine sponge as an NS3 helicase inhibitor. In this study, we evaluated...

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Bibliographic Details
Published in:Molecules
Main Authors: Salam, Kazi Abdus, Furuta, Atsushi, Noda, Naohiro, Tsuneda, Satoshi, Sekiguchi, Yuji, Yamashita, Atsuya, Moriishi, Kohji, Nakakoshi, Masamichi, Tani, Hidenori, Roy, Sona Rani, Tanaka, Junichi, Tsubuki, Masayoshi, Akimitsu, Nobuyoshi
Format: Artigo
Language:Inglês
Published: MDPI 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271602/
https://ncbi.nlm.nih.gov/pubmed/24699145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19044006
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