Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents

A series of novel ligustrazine-oleanolic acid (TOA) derivatives were designed, and synthesized by conjugating amino acids to the 3-hydroxy group of TOA by ester bonds. Their cytotoxicity was evaluated on four cancer cell lines (HepG2, HT-29, Hela and BGC-823) by standard MTT assays. The ClogP values...

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Udgivet i:Molecules
Main Authors: Chu, Fuhao, Xu, Xin, Li, Guoliang, Gu, Shun, Xu, Kuo, Gong, Yan, Xu, Bing, Wang, Mina, Zhang, Huazheng, Zhang, Yuzhong, Wang, Penglong, Lei, Haimin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271079/
https://ncbi.nlm.nih.gov/pubmed/25387350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191118215
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