Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway

It has been established that oximes cause endothelium-independent relaxation in blood vessels. In the present study, the cardiovascular effects of the new oxime 3-hydroxy-4–(hydroxyimino)-2-(3-methylbut-2-enylnaphtalen-1(4H)-one (OximeS1) derived from lapachol were evaluated. In normotensive rats, a...

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Publicat a:Molecules
Autors principals: Dantas, Bruna P. V., Ribeiro, Thaís P., Assis, Valéria L., Furtado, Fabíola F., Assis, Kívia S., Alves, Jeziane S., Silva, Tania M.S., Camara, Celso A., França-Silva, Maria S., Veras, Robson C., Medeiros, Isac A., Alencar, Jacicarlos L., Braga, Valdir A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270866/
https://ncbi.nlm.nih.gov/pubmed/25006785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19079773
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