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Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling

Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH to attenuate heme synthesis downregulates eNO...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Bin, Alruwaili, Norah, Kandhi, Sharath, Deng, Wensheng, Huang, An, Wolin, Michael S., Sun, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037352/
https://ncbi.nlm.nih.gov/pubmed/29985945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200307
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