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Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling
Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH to attenuate heme synthesis downregulates eNO...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6037352/ https://ncbi.nlm.nih.gov/pubmed/29985945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200307 |
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