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Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
Antifungal resistance due to upregulation of efflux pumps is prevalent in clinical Candida isolates. Potential efflux pump substrates (PEPSs), which are active against strains deficient in efflux pumps but inactive against wild-type strains, are usually missed in routine antifungal screening. Here w...
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| 發表在: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6269435/ https://ncbi.nlm.nih.gov/pubmed/30504815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07633-9 |
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