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Compounds that select against the tetracycline resistance efflux pump

We developed a competition-based screening strategy to identify compounds that invert the selective advantage of antibiotic resistance. Using our assay, we screened over 19,000 compounds for the ability to select against the TetA tetracycline resistance efflux pump in E. coli and identified two hits...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Stone, Laura K., Baym, Michael, Lieberman, Tami D., Chait, Remy, Clardy, Jon, Kishony, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069154/
https://ncbi.nlm.nih.gov/pubmed/27642863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2176
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