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Compounds that select against the tetracycline resistance efflux pump

We developed a competition-based screening strategy to identify compounds that invert the selective advantage of antibiotic resistance. Using our assay, we screened over 19,000 compounds for the ability to select against the TetA tetracycline resistance efflux pump in E. coli and identified two hits...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Chem Biol
Egile Nagusiak: Stone, Laura K., Baym, Michael, Lieberman, Tami D., Chait, Remy, Clardy, Jon, Kishony, Roy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069154/
https://ncbi.nlm.nih.gov/pubmed/27642863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2176
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