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Mechanistic Study of the Spiroindolones: A New Class of Antimalarials
During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the 4E and 4Z imine intermediates, a systematic mechanistic study of the reaction under both kinetic and thermodynamic conditions...
Sparad:
| I publikationen: | Molecules |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
MDPI
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6268731/ https://ncbi.nlm.nih.gov/pubmed/22922283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules170910131 |
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