α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway

Skeletal muscle atrophy due to excessive protein degradation is the main cause for muscle dysfunction, fatigue, and weakening of athletic ability. Endurance exercise is effective to attenuate muscle atrophy, but the underlying mechanism has not been fully investigated. α-Ketoglutarate (AKG) is a key...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Cai, Xingcai, Yuan, Yexian, Liao, Zhengrui, Xing, Kongping, Zhu, Canjun, Xu, Yaqiong, Yu, Lulu, Wang, Lina, Wang, Songbo, Zhu, Xiaotong, Gao, Ping, Zhang, Yongliang, Jiang, Qingyan, Xu, Pingwen, Shu, Gang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6266637/
https://ncbi.nlm.nih.gov/pubmed/28939592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700670R
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