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Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells
The protein p53 protects the organism against carcinogenic events by the induction of cell cycle arrest and DNA repair program upon DNA damage. Virtually all cancers inactivate p53 either by mutations/deletions of the TP53 gene or by boosting negative regulation of p53 activity. The overexpression o...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6266412/ https://ncbi.nlm.nih.gov/pubmed/30352966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10110396 |
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