Dynamin impacts homology-directed repair and breast cancer response to chemotherapy

After the initial responsiveness of triple-negative breast cancers (TNBCs) to chemotherapy, they often recur as chemotherapy-resistant tumors, and this has been associated with upregulated homology-directed repair (HDR). Thus, inhibitors of HDR could be a useful adjunct to chemotherapy treatment of...

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Publicado en:J Clin Invest
Autores principales: Chernikova, Sophia B., Nguyen, Rochelle B., Truong, Jessica T., Mello, Stephano S., Stafford, Jason H., Hay, Michael P., Olson, Andrew, Solow-Cordero, David E., Wood, Douglas J., Henry, Solomon, von Eyben, Rie, Deng, Lei, Gephart, Melanie Hayden, Aroumougame, Asaithamby, Wiese, Claudia, Game, John C., Győrffy, Balázs, Brown, J. Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264728/
https://ncbi.nlm.nih.gov/pubmed/30371505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87191
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