Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors

Raltegravir was the first HIV-1 integrase inhibitor that gained FDA approval for use in the treatment of HIV-1 infection. Because of the emergence of IN inhibitor-resistant viral strains, there is a need to identify innovative second-generation IN inhibitors. Previously, we identified 2-thioxo-4-thi...

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Pubblicato in:Molecules
Autori principali: Ramkumar, Kavya, Yarovenko, Vladimir N., Nikitina, Alexandra S., Zavarzin, Igor V., Krayushkin, Mikhail M., Kovalenko, Leonid V., Esqueda, Adrian, Odde, Srinivas, Neamati, Nouri
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264390/
https://ncbi.nlm.nih.gov/pubmed/20657419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules15063958
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