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Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors

Merck's MK-0518, known as raltegravir, has recently become the first FDA-approved HIV-1 integrase (IN) inhibitor and has since risen to blockbuster drug status. Much research has in turn been conducted over the last few years aimed at recreating but optimizing the compound's interactions w...

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Detalhes bibliográficos
Main Authors: Serrao, Erik, Odde, Srinivas, Ramkumar, Kavya, Neamati, Nouri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660292/
https://ncbi.nlm.nih.gov/pubmed/19265512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-25
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