Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors

Raltegravir was the first HIV-1 integrase inhibitor that gained FDA approval for use in the treatment of HIV-1 infection. Because of the emergence of IN inhibitor-resistant viral strains, there is a need to identify innovative second-generation IN inhibitors. Previously, we identified 2-thioxo-4-thi...

Full description

Saved in:
Bibliographic Details
Published in:Molecules
Main Authors: Ramkumar, Kavya, Yarovenko, Vladimir N., Nikitina, Alexandra S., Zavarzin, Igor V., Krayushkin, Mikhail M., Kovalenko, Leonid V., Esqueda, Adrian, Odde, Srinivas, Neamati, Nouri
Format: Artigo
Language:Inglês
Published: MDPI 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264390/
https://ncbi.nlm.nih.gov/pubmed/20657419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules15063958
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items