Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

Cell migration often involves the formation of sheet-like lamellipodia generated by branched actin filaments. The branches are initiated when Arp2/3 complex [1] is activated by WAVE regulatory complex (WRC) downstream of small GTPases of the Rac family [2]. Recent structural studies defined two inde...

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Vydáno v:Curr Biol
Hlavní autoři: Schaks, Matthias, Singh, Shashi P., Kage, Frieda, Thomason, Peter, Klünemann, Thomas, Steffen, Anika, Blankenfeldt, Wulf, Stradal, Theresia E., Insall, Robert H., Rottner, Klemens
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264382/
https://ncbi.nlm.nih.gov/pubmed/30393033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2018.10.002
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