The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts

Mitochondrial DNA mutations accumulate with age and may play a role in stem cell aging as suggested by the premature aging phenotype of mitochondrial DNA polymerase gamma (POLG) exonuclease-deficient mice. Therefore, E1A immortalized murine embryonic fibroblasts (MEFs) from POLG exonuclease-deficien...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biol Open
Principais autores: Delic, Vedad, Noble, Kenyaria, Zivkovic, Sandra, Phan, Tam-Anh, Reynes, Christian, Zhang, Yumeng, Phillips, Oluwakemi, Claybaker, Charles, Ta, Yen, Dinh, Vinh B., Cruz, Josean, Prolla, Tomas A., Bradshaw, Patrick C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262855/
https://ncbi.nlm.nih.gov/pubmed/30177551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.033852
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados