The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts

Mitochondrial DNA mutations accumulate with age and may play a role in stem cell aging as suggested by the premature aging phenotype of mitochondrial DNA polymerase gamma (POLG) exonuclease-deficient mice. Therefore, E1A immortalized murine embryonic fibroblasts (MEFs) from POLG exonuclease-deficien...

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Detalles Bibliográficos
Publicado en:Biol Open
Main Authors: Delic, Vedad, Noble, Kenyaria, Zivkovic, Sandra, Phan, Tam-Anh, Reynes, Christian, Zhang, Yumeng, Phillips, Oluwakemi, Claybaker, Charles, Ta, Yen, Dinh, Vinh B., Cruz, Josean, Prolla, Tomas A., Bradshaw, Patrick C.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262855/
https://ncbi.nlm.nih.gov/pubmed/30177551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.033852
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