LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Integrins are α/β heterodimers that interconvert between inactive and active states. In the active state the α/β cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the α/β TMcy...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Tseng, Hui-yuan, Samarelli, Anna V., Kammerer, Patricia, Scholze, Sarah, Ziegler, Tilman, Immler, Roland, Zent, Roy, Sperandio, Markus, Sanders, Charles R., Fässler, Reinhard, Böttcher, Ralph T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262777/
https://ncbi.nlm.nih.gov/pubmed/30333137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.218214
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