An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia

Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds with T3SS inhibitory activity have been identified...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Morgan, Jessica M., Lam, Hanh N., Delgado, Jocelyn, Luu, Justin, Mohammadi, Sina, Isberg, Ralph R., Wang, Helen, Auerbuch, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262202/
https://ncbi.nlm.nih.gov/pubmed/30524970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00404
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