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IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis
The anti-tuberculosis (TB) agent IMB-T130 was speculated to be a multi-target compound. In this research, we found that IMB-T130 inhibits the catalytic activity of Mycobacterium tuberculosis 3-dehydroquinate synthase (MtDHQS), the enzyme in the second step of the shikimate pathway. IMB-T130 was iden...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6262012/ https://ncbi.nlm.nih.gov/pubmed/30487577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35701-z |
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