Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

ApoE4 genotype is the most prevalent and also clinically most important risk factor for late-onset Alzheimer’s disease (AD). Available evidence suggests that the root cause for this increased risk is a trafficking defect at the level of the early endosome. ApoE4 differs from the most common ApoE3 is...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Xian, Xunde, Pohlkamp, Theresa, Durakoglugil, Murat S, Wong, Connie H, Beck, Jürgen K, Lane-Donovan, Courtney, Plattner, Florian, Herz, Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Human Biology and Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261251/
https://ncbi.nlm.nih.gov/pubmed/30375977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40048
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