ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

Apolipoprotein E (ApoE) genotype is a powerful genetic modifier of Alzheimer's disease (AD). The ApoE4 isoform significantly reduces the mean age-of-onset of dementia through unknown mechanisms. Here, we show that ApoE4 selectively impairs synaptic plasticity and NMDA receptor phosphorylation b...

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Main Authors: Chen, Ying, Durakoglugil, Murat S., Xian, Xunde, Herz, Joachim
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900641/
https://ncbi.nlm.nih.gov/pubmed/20547867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914984107
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