Levofloxacin Pharmacokinetics/Pharmacodynamics, Dosing, Susceptibility Breakpoints, and Artificial Intelligence in the Treatment of Multidrug-resistant Tuberculosis

BACKGROUND: Levofloxacin is used for the treatment of multidrug-resistant tuberculosis; however the optimal dose is unknown. METHODS: We used the hollow fiber system model of tuberculosis (HFS-TB) to identify 0–24 hour area under the concentration-time curve (AUC(0-24)) to minimum inhibitory concent...

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Veröffentlicht in:Clin Infect Dis
Hauptverfasser: Deshpande, Devyani, Pasipanodya, Jotam G, Mpagama, Stellah G, Bendet, Paula, Srivastava, Shashikant, Koeuth, Thearith, Lee, Pooi S, Bhavnani, Sujata M, Ambrose, Paul G, Thwaites, Guy, Heysell, Scott K, Gumbo, Tawanda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Supplement Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260169/
https://ncbi.nlm.nih.gov/pubmed/30496461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy611
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