A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground

Children with tuberculosis are treated with drug regimens copied from adults despite significant differences in antibiotic pharmacokinetics, pathology, and the microbial burden between childhood and adult tuberculosis. We sought to develop a new and effective oral treatment regimen specific to child...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Srivastava, Shashikant, Deshpande, Devyani, Pasipanodya, Jotam G., Thomas, Tania, Swaminathan, Soumya, Nuermberger, Eric, Gumbo, Tawanda
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
A Development Paradigm for Novel Combination Regimens for Multidrug-Resistant and Drug-Susceptible Tuberculosis in Children: Flame for Work and Play
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064153/
https://ncbi.nlm.nih.gov/pubmed/27742637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciw472
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