A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground

Children with tuberculosis are treated with drug regimens copied from adults despite significant differences in antibiotic pharmacokinetics, pathology, and the microbial burden between childhood and adult tuberculosis. We sought to develop a new and effective oral treatment regimen specific to child...

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Publicat a:Clin Infect Dis
Autors principals: Srivastava, Shashikant, Deshpande, Devyani, Pasipanodya, Jotam G., Thomas, Tania, Swaminathan, Soumya, Nuermberger, Eric, Gumbo, Tawanda
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
A Development Paradigm for Novel Combination Regimens for Multidrug-Resistant and Drug-Susceptible Tuberculosis in Children: Flame for Work and Play
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064153/
https://ncbi.nlm.nih.gov/pubmed/27742637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciw472
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