Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests

Background. The role of drug concentrations in clinical outcomes in children with tuberculosis is unclear. Target concentrations for dose optimization are unknown. Methods. Plasma drug concentrations measured in Indian children with tuberculosis were modeled using compartmental pharmacokinetic analy...

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Détails bibliographiques
Publié dans:Clin Infect Dis
Auteurs principaux: Swaminathan, Soumya, Pasipanodya, Jotam G., Ramachandran, Geetha, Hemanth Kumar, A. K., Srivastava, Shashikant, Deshpande, Devyani, Nuermberger, Eric, Gumbo, Tawanda
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
A Development Paradigm for Novel Combination Regimens for Multidrug-Resistant and Drug-Susceptible Tuberculosis in Children: Flame for Work and Play
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064152/
https://ncbi.nlm.nih.gov/pubmed/27742636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciw471
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