Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests

Background. The role of drug concentrations in clinical outcomes in children with tuberculosis is unclear. Target concentrations for dose optimization are unknown. Methods. Plasma drug concentrations measured in Indian children with tuberculosis were modeled using compartmental pharmacokinetic analy...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Infect Dis
Egile Nagusiak: Swaminathan, Soumya, Pasipanodya, Jotam G., Ramachandran, Geetha, Hemanth Kumar, A. K., Srivastava, Shashikant, Deshpande, Devyani, Nuermberger, Eric, Gumbo, Tawanda
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
A Development Paradigm for Novel Combination Regimens for Multidrug-Resistant and Drug-Susceptible Tuberculosis in Children: Flame for Work and Play
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064152/
https://ncbi.nlm.nih.gov/pubmed/27742636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciw471
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