Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests

Background. The role of drug concentrations in clinical outcomes in children with tuberculosis is unclear. Target concentrations for dose optimization are unknown. Methods. Plasma drug concentrations measured in Indian children with tuberculosis were modeled using compartmental pharmacokinetic analy...

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Udgivet i:Clin Infect Dis
Main Authors: Swaminathan, Soumya, Pasipanodya, Jotam G., Ramachandran, Geetha, Hemanth Kumar, A. K., Srivastava, Shashikant, Deshpande, Devyani, Nuermberger, Eric, Gumbo, Tawanda
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
A Development Paradigm for Novel Combination Regimens for Multidrug-Resistant and Drug-Susceptible Tuberculosis in Children: Flame for Work and Play
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064152/
https://ncbi.nlm.nih.gov/pubmed/27742636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciw471
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