Ethionamide Pharmacokinetics/Pharmacodynamics-derived Dose, the Role of MICs in Clinical Outcome, and the Resistance Arrow of Time in Multidrug-resistant Tuberculosis

BACKGROUND: Ethionamide is used to treat multidrug-resistant tuberculosis (MDR-TB). The antimicrobial pharmacokinetics/pharmacodynamics, the contribution of ethionamide to the multidrug regimen, and events that lead to acquired drug resistance (ADR) are unclear. METHODS: We performed a multidose hol...

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Publicat a:Clin Infect Dis
Autors principals: Deshpande, Devyani, Pasipanodya, Jotam G, Mpagama, Stellah G, Srivastava, Shashikant, Bendet, Paula, Koeuth, Thearith, Lee, Pooi S, Heysell, Scott K, Gumbo, Tawanda
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Supplement Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260165/
https://ncbi.nlm.nih.gov/pubmed/30496457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy609
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