Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer's Disease Treatment

A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was deter...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Korabecny, Jan, Musilek, Kamil, Holas, Ondrej, Nepovimova, Eugenie, Jun, Daniel, Zemek, Filip, Opletalova, Veronika, Patocka, Jiri, Dohnal, Vlastimil, Nachon, Florian, Hroudova, Jana, Fisar, Zdenek, Kuca, Kamil
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2010
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6259100/
https://ncbi.nlm.nih.gov/pubmed/21127466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules15128804
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