Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate

Whole-sporozoite vaccination/immunization induces high levels of protective immunity in both rodent models of malaria and in humans. Recently, we generated a transgenic line of the rodent malaria parasite P. berghei (Pb) that expresses the P. falciparum (Pf) circumsporozoite protein (PfCS), and show...

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Udgivet i:NPJ Vaccines
Main Authors: Mendes, António M., Reuling, Isaie J., Andrade, Carolina M., Otto, Thomas D., Machado, Marta, Teixeira, Filipa, Pissarra, Joana, Gonçalves-Rosa, Nataniel, Bonaparte, Dolores, Sinfrónio, João, Sanders, Mandy, Janse, Chris J., Khan, Shahid M., Newbold, Chris I., Berriman, Matthew, Lee, Cynthia K., Wu, Yimin, Ockenhouse, Christian F., Sauerwein, Robert W., Prudêncio, Miguel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258718/
https://ncbi.nlm.nih.gov/pubmed/30510775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0091-3
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