Use of a Gamma-2 Herpesvirus as a Vector to Deliver Antibodies to Rhesus Monkeys

The gamma-2 herpesvirus of rhesus monkeys, rhesus monkey rhadinovirus (RRV), persists principally in B cells of its host. We constructed recombinant strains of RRV expressing the rhesus monkey-derived anti-SIV monoclonal antibodies 4L6 and 5L7 and compared the RRV-mediated in vivo delivery of these...

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Publicat a:Gene Ther
Autors principals: Bischof, Georg F., Shin, Young C., Fuchs, Sebastian P., Martinez-Navio, José M, Lauer, William A., Rakasz, Eva G., Desrosiers, Ronald C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258056/
https://ncbi.nlm.nih.gov/pubmed/28660888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.49
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