Molecular Basis of the Leishmanicidal Activity of the Antidepressant Sertraline as a Drug Repurposing Candidate

Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin. The antidepressant sertraline has been successfully assayed in a murine model of visceral leishmaniasis. Nevertheless, sert...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Lima, Marta L., Abengózar, María A., Nácher-Vázquez, Montserrat, Martínez-Alcázar, María P., Barbas, Coral, Tempone, Andre G., López-Gonzálvez, Ángeles, Rivas, Luis
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2018
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Mechanisms of Action: Physiological Effects
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256786/
https://ncbi.nlm.nih.gov/pubmed/30297370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01928-18
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