Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth

Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival and chemotherapy resistance. While normal cells often rely on extracellular serine and glycine supply, a significant subset of cancers becomes addicted to intracellular serine/glycine synthesis, offering an attractive dr...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Geeraerts, Shauni Lien, Kampen, Kim Rosalie, Rinaldi, Gianmarco, Gupta, Purvi, Planque, Mélanie, Louros, Nikolaos, Heylen, Elien, De Cremer, Kaat, De Brucker, Katrijn, Vereecke, Stijn, Verbelen, Benno, Vermeersch, Pieter, Schymkowitz, Joost, Rousseau, Frederic, Cassiman, David, Fendt, Sarah-Maria, Voet, Arnout, Cammue, Bruno P.A., Thevissen, Karin, De Keersmaecker, Kim
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611204/
https://ncbi.nlm.nih.gov/pubmed/33203732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0480
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