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Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor

AIMS: Filgotinib (GS‐6034, formerly GLPG0634) is an oral, selective Janus kinase 1 (JAK1) inhibitor that showed early response and sustained efficacy in patients with rheumatoid arthritis and with Crohn's disease. The aim of the present study was to investigate the impact of age and renal impai...

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Bibliografiska uppgifter
I publikationen:Br J Clin Pharmacol
Huvudupphovsmän: Namour, Florence, Fagard, Liesbeth, Van der Aa, Annegret, Harrison, Pille, Xin, Yan, Tasset, Chantal
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256002/
https://ncbi.nlm.nih.gov/pubmed/30088677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13726
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