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Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor

AIMS: Filgotinib (GS‐6034, formerly GLPG0634) is an oral, selective Janus kinase 1 (JAK1) inhibitor that showed early response and sustained efficacy in patients with rheumatoid arthritis and with Crohn's disease. The aim of the present study was to investigate the impact of age and renal impai...

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Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: Namour, Florence, Fagard, Liesbeth, Van der Aa, Annegret, Harrison, Pille, Xin, Yan, Tasset, Chantal
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256002/
https://ncbi.nlm.nih.gov/pubmed/30088677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13726
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