Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, in Support of Phase IIB Dose Selection

BACKGROUND AND OBJECTIVES: Filgotinib (GLPG0634) is a selective inhibitor of Janus kinase 1 (JAK1) currently in development for the treatment of rheumatoid arthritis and Crohn’s disease. While less selective JAK inhibitors have shown long-term efficacy in treating inflammatory conditions, this was a...

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Vydáno v:Clin Pharmacokinet
Hlavní autoři: Namour, Florence, Diderichsen, Paul Matthias, Cox, Eugène, Vayssière, Béatrice, Van der Aa, Annegret, Tasset, Chantal, Van‘t Klooster, Gerben
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2015
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Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513223/
https://ncbi.nlm.nih.gov/pubmed/25681059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0240-z
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