Population Pharmacokinetic and Pharmacodynamic Analysis of GLPG1690, an Autotaxin Inhibitor, in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis

BACKGROUND AND OBJECTIVES: GLPG1690 is an autotaxin inhibitor in development for the treatment of idiopathic pulmonary fibrosis. Several publications suggested a role of autotaxin in the control of disease-affected lung function and of lysophosphatidic acid in lung remodeling processes. The aim of t...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Taneja, Amit, Desrivot, Julie, Diderichsen, Paul Matthias, Blanqué, Roland, Allamasey, Lisa, Fagard, Liesbeth, Fieuw, Ann, Van der Aar, Ellen, Namour, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719325/
https://ncbi.nlm.nih.gov/pubmed/30953319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-019-00755-3
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